His first movie appearance was as the Great Ahmed Kahn in Network (1976). A prolific voice actor during the 1980s, his most celebrated roles were Destro in the animated series G.I. Joe and Devastator on The Transformers. He also played the voice of Venom in Ultimate Spider-Man. He also played Turbo in Challenge of the Gobots. Burghardt appeared in the series premiere of the short-lived 1991 sitcom Good Sports with Ryan O’Neal and Farrah Fawcett. In 1997, he was the voice of “Cy” in the family science fiction movie Star Kid. Arthur portrayed as Laurant in the 2001 hit TV series, Los Luchadores.
He also played a commando in the early-1990s video game Night Trap. In Warcraft III: Reign of Chaos, he voiced Mannoroth and Grom Hellscream in 2002, and later in World of Warcraft: Cataclysm he reprised his role as Mannoroth. In 2010 he voiced Thanatos in God of War: Ghost of Sparta.